Black pepper is one of the important medicinal materials as a traditional herb used to treat many diseases. As early as the late 19th century, piperine, the main component of pepper, has been purified and synthesized [1]. This product is Piper nigrum L. Dried nearly ripe or mature fruit. From the end of autumn to the next spring when the fruit is dark green, dried, black pepper. Piperine is a broad-spectrum anticonvulsant. It has good anti-convulsion effect on experimental electroconvulsion in mice. It also has different anti-effect on convulsive seizures and audiogenic seizures caused by pentatetrazine, tetrandrine, strychnine, as well as convulsive seizures caused by intraventricular injection of turocurine and glutamic acid. It can also help with certain types of epilepsy. Piperine is more toxic to flies than pyrethrum.