Guggul extract, derived from the resin of the Commiphora mukul tree, has been a cornerstone of traditional Ayurvedic medicine for thousands of years. Native to India, this small, thorny tree produces a gum resin that is harvested and processed to create the potent extract. Guggul is renowned for its wide array of health benefits, particularly its anti-inflammatory, antioxidant, and lipid-lowering properties. It has been traditionally used to treat a variety of conditions, including arthritis, hyperlipidemia, and obesity. The active compounds in guggul, known as guggulsterones, play a key role in its therapeutic effects by modulating lipid metabolism and exerting anti-inflammatory actions. Modern research supports many of these traditional uses, highlighting guggul extract’s potential in managing cardiovascular health, reducing cholesterol levels, and aiding in weight management. Its versatility and effectiveness make guggul extract a valuable natural remedy in both traditional and contemporary healthcare practices.